Stromectol is the brand name for the antiparasitic drug ivermectin. Ivermectin belongs to the macrocyclic lactone class of medications, primarily used to treat a variety of parasitic infections in humans. Since its original development for veterinary use, ivermectin has been adapted for human therapy, becoming one of the most commonly prescribed antiparasitic agents worldwide.
Ivermectin works against certain nematodes, arthropods and other parasites by targeting neuronal and muscle cells of the parasite. Over the decades, it has become a cornerstone in the management of onchocerciasis (river blindness), lymphatic filariasis, scabies and strongyloidiasis. While brand-name Stromectol remains a prescription-only medicine in the UK, generic versions are widely marketed, often at a substantially lower price.
Ivermectin induces paralysis and death of parasites by binding to glutamate-gated chloride channels in their nerve and muscle cells. This binding increases permeability to chloride ions, hyperpolarising the cell membrane and causing paralysis. In humans, the drug does not interact with the same channels in mammalian cells, which underlies its selective toxicity.
After oral administration, ivermectin is rapidly absorbed, with a bioavailability of approximately 60%. Peak plasma concentrations occur within 4–5 hours. It is highly lipophilic, distributing widely into tissues. Metabolism occurs predominantly in the liver via the CYP3A4 enzyme system, and metabolites are excreted primarily in the faeces.
The elimination half-life of ivermectin is approximately 18 hours, but terminal half-life may extend to 2–3 days. Renal excretion of unchanged drug is minimal (<1%), so dose adjustment in mild to moderate renal impairment is generally not required. Caution is advised in severe hepatic impairment.
In the UK, the licensed indications for Stromectol include:
Although not licensed for certain off-label uses, ivermectin has been studied in various settings such as rosacea, head lice, demodicosis and emerging viral applications. Patients should always consult a healthcare professional before using ivermectin for any non-licensed indication.
For parasitic worms (onchocerciasis, filariasis, strongyloidiasis), the usual dose is a single oral dose of 150–200 µg/kg body weight. This weight-based dosing is often rounded down to the nearest available tablet strength to ensure safety.
| Body weight | Calculated dose (µg/kg) | Tablets (3 mg each) |
|---|---|---|
| 50 kg | 8–10 mg | 3 mg × 3 tablets = 9 mg |
| 70 kg | 10.5–14 mg | 3 mg × 4 tablets = 12 mg |
| 90 kg | 13.5–18 mg | 3 mg × 5 tablets = 15 mg |
For crusted or severe scabies, two doses of 200 µg/kg may be given 7–14 days apart. Mild cases may respond to a single dose, but repeat dosing is often recommended to ensure eradication of newly hatched mites.
Stromectol and its generic equivalents are available for purchase through various online pharmacies. When you search for “buy Stromectol without prescription” or “order generic ivermectin cheaper online in the UK”, you will encounter a range of options. Key factors to consider include:
Elstree Pharmacy offers genuine generic ivermectin at competitive prices. Our streamlined online ordering system allows you to place an order without prescription and receive your package discreetly at your doorstep.
The price of generic Stromectol (ivermectin) can vary by pack size, supplier and promotional offers. As a guide:
| Product | Strength | Pack size | Approx. price (GBP) | Status |
|---|---|---|---|---|
| Generic Ivermectin | 3 mg | 10 tablets | £12.50 | In stock |
| Generic Ivermectin | 6 mg | 10 tablets | £18.00 | In stock |
| Stromectol | 3 mg | 6 tablets | £45.00 | Prescription Only |
Prices online may be lower, with bulk or repeat-purchase discounts available. To ensure you buy cheap but genuine ivermectin, choose a regulated online pharmacy like Elstree Pharmacy.
Generic ivermectin contains the same active API (active pharmaceutical ingredient) as branded Stromectol. Regulatory authorities require generics to meet strict standards for bioequivalence, safety and efficacy. Differences may occur in:
Generic products can offer substantial savings—often 50–70% cheaper—without compromising quality. When you purchase generic ivermectin, you gain access to the same therapeutic benefits at a much lower cost.
In the UK, ivermectin (Stromectol) is classified as a Prescription Only Medicine (POM). Selling or supplying it without a valid prescription is generally not permitted under MHRA regulations. However, some online pharmacies outside the UK operate in a legal grey area, offering “without prescription” purchase options.
Elstree Pharmacy provides comprehensive advice and may facilitate purchase under a patient-specific prescription framework. Claims of “order without prescription” should always be backed by a professional consultation or valid prescription supplied electronically.
Ivermectin is metabolised by CYP3A4 and may interact with strong inhibitors or inducers of this enzyme. Notable interactions include:
| Medication | Effect |
|---|---|
| Ketoconazole | Increases ivermectin levels |
| Rifampicin | Decreases ivermectin levels |
| Warfarin | May alter INR; monitor coagulation parameters |
Always inform your pharmacy or prescriber about concurrent medicines, supplements and herbal remedies.
Most individuals tolerate ivermectin well. Common side effects include:
Less common but serious reactions may involve:
If you experience severe or unexpected symptoms, stop treatment and seek medical attention immediately.
Ivermectin is pregnancy category C. Animal studies have shown some risk at high doses; human data are limited. Breastfeeding mothers should use caution, as ivermectin is excreted in breast milk.
Use in children under 5 years or under 15 kg is not routinely recommended without specialist advice. Dosing must be carefully calculated by body weight.
Elderly patients may have altered pharmacokinetics due to changes in hepatic or renal function. Monitor for adverse effects and adjust dose only if clinically indicated.
Ivermectin resistance has been documented in veterinary parasitology, but clinically significant resistance in human parasites remains rare. Surveillance programs continue to monitor efficacy, particularly in mass drug administration (MDA) campaigns against onchocerciasis and lymphatic filariasis.
Recent research explores novel uses of ivermectin beyond parasitic diseases, including antiviral and anticancer properties. These off-label applications remain experimental and should not replace proven therapies.
